W. Zeng, S. Chemler
Jun 28, 2008
Citations
0
Influential Citations
56
Citations
Journal
The Journal of organic chemistry
Abstract
The enantioselective synthesis of (S)-(+)-tylophorine, a potent cancer cell growth inhibitor, has been accomplished in eight steps from commercially available 3,4-dimethoxybenzyl alcohol. A copper (II)-catalyzed enantioselective intramolecular alkene carboamination was employed as the key step to construct the chiral indolizidine ring.