Blane P. Zavesky, Nicholas R. Babij, J. Wolfe
Sep 8, 2014
Citations
0
Influential Citations
43
Citations
Journal
Organic Letters
Abstract
A new method for the synthesis of 2-aminoimidazole products is described. The heterocyclic products are generated in good yields via Pd-catalyzed carboamination reactions of N-propargyl guanidines and aryl triflates. This methodology generates both a C–N and C–C bond during the annulation step and facilitates the rapid construction of 2-aminoimidazole products with different aryl groups. The utility of this methodology was demonstrated in the total synthesis of preclathridine A, preclathridine B, and dorimidazole B from a single intermediate.