Kunming Jiang, Jing-An Kang, Yi Jin
Jan 30, 2018
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Influential Citations
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Journal
Organic chemistry frontiers
Abstract
A new method to construct 4-hydroxyalkyl-quinoline derivatives is described via Cu(I) and Au(I) sequential catalyzed cyclization of anilines with aldehyde derivatives and aliphatic alkynes, respectively. The three-component cascade reaction provides an efficient approach for easy access to various new quinoline-based derivatives and quinoline containing an aliphatic chain substituent at the 4-position with high yields.