Ju liu Ju liu, Jian tao Shi Jian tao Shi, Xue chen Hao Xue chen Hao
2019
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Journal
Journal of the chemical society of pakistan
Abstract
A series of novel substituted 2-amino-4H-benzo[h]chromene-3-carbonitrile derivatives was synthesised by condensation of different halogen derivatives with the hydroxy-group of 2-amino-8-hydroxy-4-styryl- 4H-benzo[h]chromene-3-carbonitrile and 2-amino-8-hydroxy-4- phenethyl-4H-benzo-[h]chromene-3-carbonitrile, which were prepared from cinnamaldehyde, malononitrile and naphthalene-1,6-diol through Knoevenagel condensation and cyclization reaction and then reduction with hydrogen in the presence of Pd/C at room temperature. Each intermediates and target compounds were obtained in good yields.