C. Mirkin, Kuang‐Lieh Lu, T. Snead
Mar 28, 1990
Citations
0
Influential Citations
13
Citations
Journal
Journal of the American Chemical Society
Abstract
The pyridinone ring is an integral unit of many important molecules. 2-Pyridinones in particular have therapeutic value and are versatile synthetic intermediates for many alkaloids. A continuing need exists for improved synthetic routes to pyridinones that tolerate a wide variety of substituents with a high degree of regiospecificity in ring substitution. Previous organometallic routes to 2-pyridinones have generally involved regiospecific coupling of two alkynes with an isocyanate, yielding tri- or pentasubstituted products. Reported herein is a complementary but mechanistically different metal-assisted route to mono-, di-, and trisubstituted 2-pyridinones involving reaction of Fe{sub 2}({mu}-CH{sub 2})(CO){sub 8} with phosphinimines and alkynes.