R. W. Goettsch, G. Wiese
May 1, 1958
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Journal of the American Pharmaceutical Association. American Pharmaceutical Association
Abstract
Thianaphthene-2-carboxylic acid, thianaphthene-2-carboxamide and nineteen substituted thianaphthene-2-carboxamides were prepared. All of the compounds were screened for their antifungal activity against Trichophyton rubrum and those compounds which appeared to be equal to or more active than undecylenic acid were tested against three other pathogenic fungi. The in vitro activity of the compounds was compared to the activity of three known antifungal agents: undecylenic acid, salicylanilide, and 5-chloro-8-hydroxyquinoline. Of all of the compounds tested, N-(2-methylpiperidyl)-thianaphthene-2-carboxamide, N-cyclohexylthianaphthene-2-carboxamide, and N-morpholinylthianaphthene-2-carboxamide were the most active against all four of the fungi.