Lu Chan-ting
2005
Citations
0
Influential Citations
0
Citations
Journal
Modern Chemical Industry
Abstract
Sulfadiazine-polylactide,a tumor targeting drug carrier,was successfully synthesized by the phase transfer catalysis(PTC)with tetrabutyl ammonium chloride hydroxide as catalyst.Sulfadiazine-polylactide introduced sulfadiazine by sulfonic acid amide group to hydroxyl group side of biodegradable polylactide.This new copolymer has sulfadiazine functional groups at one end of the polymer.It was characterized by IR,H-NMR,DSC,XRD and UV.The glass-transitional temperature(T_g)and melting point(T_m)were found.As expected,the sulfadiazine-polylactide has a higer T_g and a lower T_m compared with polylactide,the changing of T_g and T_m is 56.85℃ to 59.42℃ and 181.11℃ to 175.23℃,respectively.