Liu Yang
2008
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Chemical Reagents
Abstract
9-Amino(9-deoxy)epicinchonine was synthesized from cinchonine through the Mitsunobu reaction followed by treating with 8-quinolinesulfonyl chloride,benzenesulfonyl chloride,p-toluenesulfonyl chloride,4chlorobenzenesulfonyl chloride,respectively,to give four chiral sulfonamides.These sulfonamides were used as ligands in asymmetric transfer hydrongenation of acetophenone.When the reaction was carried out using a feed rate of acetophenone∶chiral sulfonamide Ru(Ⅱ) complex∶KOH(molar ratio)=50∶1∶2.5 at 80 ℃,a maximum 96.0% conversion was obtained.