A. V. Tverdokhlebov, A. Andrushko, A. Tolmachev
May 1, 2006
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Influential Citations
10
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Journal
Synthesis
Abstract
(Arylsulfonyl)acetonitriles were shown to react with mercaptoacetic acid in refluxing pyridine yielding 2-[(arylsulfonyl)methylidene]thiazolidin-4-ones. The latter underwent alkylation with α-bromoketones in the presence of K 2 CO 3 selectively at the nitrogen atom. Further formylation of the resulting phenacyl derivatives with excess DMF-POCl 3 complex afforded 5-aroyl-7-aryl-sulfonyl-2-[(dimethylamino)methylidene]pyrrolo[2,1-b]thiazol-3(2H)-ones.