Shi Gui-zhe
2015
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Journal
Coal and Chemical Industry
Abstract
Taking 2- aminopyridine and chlorosulfonic acid as raw material, the intermediate 2- chloroimidazo [1,2- a]pyridine- 3- sulfonamide was first synthesized through the reaction of chlorosulfonation and ammonolysis. Then, five kinds of 4,6- substituted and 4,5,6- substituted 2- aminopyrimidine compounds were synthesized through condensation reaction of carbamidine and β- dicarbonyl compounds. Next, sulfonyl carbamic acid benzyl ester was obtained through the reaction of sulfonamide and phenyl chloroformate. At last, through addition reaction of the resulting compound with 2- amino pyrimidine compounds imazosulfuron and its derivates( compounds 1- 5) were obtained. The structure of the target products were analyzed and affirmed by melting point, Fourier transform infrared spectra, mass spectra, hydrogen spectra of nuclear magnetic resonance and other methods.