Fawzia Taieb Brahimi, M. Belkadi, A. Othman
May 1, 2017
Citations
0
Influential Citations
7
Citations
Journal
Arabian Journal of Chemistry
Abstract
Six azoles with n-pentyl side chain 6-9, 11 and 12 were synthesized from n-hexanoic acid. Three N-glycosides namely: 5-pentyl-2-(D-amino arabinoside)-1,3,4-oxadiazole (13), 5-pentyl-2-(D- aminoglycoside)-1,3,4-thiadiazole (14), and 3-pentyl-4-(D-amino xyloside)-4H-1,2,4-triazole-5-thiol (15) were prepared from already synthesized n-pentyl azoles 6, 7 and 11, respectively. Surface activ- ity properties of water soluble synthesized compounds 6, 7, and 11-15 were studied in terms of sur- face tension, cloud point and critical micelle concentration. The antibacterial activities were assessed using the paper disk diffusion and broth dilution methods against gram-positive and gram-negative bacteria. Some of the synthetic compounds showed promising activity against micro- organisms under test in comparison to commercially available antibiotics polymixine and oxytetra- cycline. a 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.