M. Guillaume, Jef Cuypers, Ivan Vervest
Oct 24, 2003
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Influential Citations
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Journal
Organic Process Research & Development
Abstract
A practical process to make N-(2,6-dimethylphenyl)-2-piperazin-1-yl-acetamide 1 is described, starting from piperazine 2 and N-chloroacetyl-2,6-xylidine 3. The unwanted N,N‘-bis-alkylated product 4 can be removed by simple filtration of the reaction mixture, while the excess of piperazine remains in the aqueous phase after extracting the filtrate with toluene at 70 °C. The product precipitates from the organic phase with 68% active yield.