Feng Ta
2013
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Journal
Fine Chemical Intermediates
Abstract
1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline is an important intermediate for organic synthesis. A novel process was developed for the synthesis of the title compound in an overall yield of 53% from phenethylamine. Improvements were achieved by using mixture of P2O5/ POCl3 instead of P2O5 as the dehydrating agent,less methanol, more tetrahydropyrrole and recrystallization in place of column chromatography for the purification.