R. Anumula, Lokeswara Rao Madivada, Goverdhan Gilla
Oct 31, 2008
Citations
0
Influential Citations
5
Citations
Journal
Synthetic Communications
Abstract
Abstract Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet–Spengeler type reaction and DCC (N,N′-dicyclohexylcarbodiimide)/HOBt (N-hydroxybenzotriazole)–mediated double amidation employing sarcosine ethyl ester hydrochloride.