Wang Yan-yan
2011
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Journal
Central South Pharmacy
Abstract
Objective To synthesize 1,3-dimethyl-pentylamine hydrochloride and improve the synthesis. Methods We obtained 1,3-dimethyl-pentylamine hydrochloride via 4 step reaction process from the raw material of ethyl acetoacetate and 2-butyl bromide,and synthesis was improved by single factor optimization. Results Each yield of the four reactions for 1,3-dimethyl-pentylamine hydrochloride exceeded 40%,and the overall yield was 12.3%. Conclusion The structure of 1,3-dimethyl-pentylamine hydrochloride is elucidated by 1H-NMR and 13C-NMR.