K. Jin, I. Sam, K. H. L. Po
Aug 3, 2016
Citations
2
Influential Citations
90
Citations
Quality indicators
Journal
Nature Communications
Abstract
To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.