Min Wang, Wenhui Wang, Qidong Tang
Oct 25, 2015
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Abstract
Tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate (1) is the key intermediate of Vandetanib. It was synthesized from piperidin-4-ylmethanol (2) through three steps Including acylation, sulfonation and substitution. The structures and the synthetic route were determined by MS and 1HNMR.And the synthetic method was optimized. The total yield of the three steps was 20.2%.