Joshua Almond-Thynne, Jiaxu Han, Andrew J. P. White
May 23, 2018
Citations
0
Influential Citations
3
Citations
Journal
The Journal of organic chemistry
Abstract
Efficient syntheses of both enantiomers of a spirodiamine diester from (l)- and (d)-aspartic acid are described. The key transformation was the conversion of Boc-protected tert-butyl aspartate into the derived aldehyde, two-directional Horner-Wadsworth-Emmons olefination, hydrogenation, and selective acid-catalyzed Boc-deprotection and spirocyclization. An alternative, two-directional approach to derivatives of 1,7-diazaspiro[5.5]undecane is described.