Narasimham Ayyagari, Jitendra D. Belani
Aug 18, 2014
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Influential Citations
7
Citations
Journal
Synlett
Abstract
Abstract Palladium-catalyzed oxidative cyclization of terminal-olefin-tethered phenols was achieved in good yields (61–90% yields). The reaction was optimized and White catalyst {[1,2-bis-(phenylsulfinyl)ethane]palladium(II)acetate} provided the best yield in the presence of benzoquinone as an oxidant. The reaction tolerated both electron-donating and electron-withdrawing substituents on the substrates, and the structure of the tetracyclic flavonoids was confirmed using single-crystal X-ray analysis. The study represents the first example of successful allylic C–H activation/ C–O bond formation using terminal-olefin-tethered phenols.