Abdullah M. A. Shumaila, V. Puranik, R. Kusurkar
Feb 4, 2011
Citations
0
Influential Citations
17
Citations
Journal
Tetrahedron
Abstract
Abstract Pictet–Spengler condensation of 2-(aryl)-2-(1 H -pyrrol-2-yl)ethanamines using conventional acid catalysts like TMSCl or TFA resulted in the formation of substituted 5-azaindoles involving a tandem one pot four steps reaction sequence. By contrast use of glacial acetic acid furnished the targeted tetrahydro-5-azaindoles in diastereoselective manner. These were readily dehydrogenated to 5-azaindoles.