C. A. Abdel Malak, G. I. Lavrenova, E. N. Lysogorskaya
Jan 12, 2009
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0
Influential Citations
4
Citations
Journal
International journal of peptide and protein research
Abstract
Swine pepsin at pH 5 efficiently catalyzes a condensation between Z-Ala-Ala-Phe-OH and p-nitroanilides of Leu, Phe, Val, Ala and Arg that leads to formation of corresponding benzyloxycarbonyl-tetrapeptide p-nitroanilides with yields of 70-90%. These reactions are complicated by co-precipitation of pepsin and the reaction products that necessitates the use of a relatively high concentration of pepsin.