Serge Djekou, A. Gellis, H. El-kashef
Sep 1, 2006
Citations
0
Influential Citations
8
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
7-Chloromethyl-6-nitro-5H-thiazolo[3,2-a]pyrimidin-5-one (2) is obtained by cyclocondensation of 2-aminothiazole with ethyl 4-chloroacetoacetate. This product was shown to react with various nitronate or malonate anions under microwave irradiation to give potentially bioactive 6-nitro-5H-thiazolo[3,2-a]pyrimidin-5-ones. Extension to other anions centered on S atom allows for the generalization this synthetic procedure.