Ming‐Ming Wang, Seongmin Jeon, J. Waser
Nov 10, 2020
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Influential Citations
6
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Journal
Organic letters
Abstract
We report the one-pot synthesis of 4-amino thiochromans using simple aminocyclopropanes and thiophenols through a formal [3+3] annulation reaction. This reaction proceeds under mild conditions with good functional group tolerance. The thiochroman core was formed with complete regioselectivity, and modification of complex drug molecules containing an aminocyclopropane was also realized.