C. C. Marvin, A. J. L. Clemens, S. D. Burke
Nov 30, 2007
Citations
0
Influential Citations
12
Citations
Journal
Organic letters
Abstract
Total synthesis of thromboxane B2 using intermolecular ketalization followed by ring-closing metathesis is reported. Other key steps include a Sharpless asymmetric epoxidation to form an oxirane on the endo face of the bicyclic acetal, epoxide opening using lithioacetonitrile, an allylic alcohol 1,3-transposition, and Mitsunobu lactonization.