X. Xiao
2002
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Toremifene citrate was synthesized from 4 hydroxydiphenyl ketone by two condensations to give 1,2 dibenzyl 1 [4 [2 ( N,N dimethylamino)ethoxyl]phenyl] butane 1,4 diol, chlorination and dehydration by one step reaction to afford toremifene, and then neutralization with citric acid with an overall yield of 24.7%.