R. Harvey, R. Young, C. Cortez
1993
Citations
0
Influential Citations
10
Citations
Journal
Journal of Organic Chemistry
Abstract
Cyclopenta[a]phenanthrenes are a unique class of carcinogenic polycyclic aromatic hydrocarbons that are structurally relallad to steroids. Optimum tumorigenic activity is ansociated with a methyl group in the 11-position and a keto group in the 17-position. Syntheses of the putative active trans-3,4-dihydrodiol and anti- and syn-diol epoxide metabolites of cyclopenta[a]phenanthrene and its 11-methyl derivative are described in the preceding paper. This paper reports the syntheses of the analogous trans-3,4-dihydrodiol derivatives of these same hydrocarbons with a 17-carbonyl function