Changmei Si, Wei Huang, Zhenting Du
Aug 1, 2014
Citations
0
Influential Citations
48
Citations
Journal
Organic letters
Abstract
A diastereoselective one-pot approach to access trans-5-hydroxy-6-substituted-2-piperidinones by an addition-cyclization-deprotection process has been developed, in which the stereogenic center at the C-6 position was solely controlled by α-OTBS group. The utility of this transformation is demonstrated by the asymmetric synthesis of the enantiomer of (-)-CP-99,994.