P. Onys'ko, O. I. Kyselyova, Kateryna A. Zamulko
May 1, 2015
Citations
0
Influential Citations
2
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract A convenient synthetic approach for previously unknown 1-chloro-2,2,2-trifluoroethyl isocyanate, based on reaction of easily accessible N-(2,2,2-trifluoroethyl-1-hydroxy)-O-ethylcarbamate with thionyl chloride and/or phosphorus pentachloride, was developed. The synthetic potential of the isocyanate as novel bielectrophilic building block was demonstrated by its easy functionalization with N- and O-centered nucleophiles involving participation of one or both electrophilic centers of the C N C triad.