R. Baltrushis, Z. I. G. Beresnevichyus, V. Mitskyavichyus
Oct 1, 1982
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Journal
Chemistry of Heterocyclic Compounds
Abstract
N-(4-Hydroxyphenyl)-β-alanine and its methyl derivatives, as well as p-hydroxyphenylamino-β, β'-dipropionic acid, were obtained by the reaction of p-aminophenol with methyl acrylate and acrylic, methacrylic, and crotonic acids. The β-alanines were converted to the corresponding hydrazides and 1-(4-hydroxyphenyl)dihydro- and thiodihydrouracils, which were decyclized by the action of alkalis to ureido and thioureido acids and were dehydrogenated by heating with sulfur to give uracils. The dihydro- and thiodihydrouracils were alkylated and acetylated.