P. N. Patel, Y. Patel
May 27, 2015
Citations
0
Influential Citations
3
Citations
Journal
Cogent Chemistry
Abstract
Abstract Present communication deals with the synthesis and characterization of various spiro thiazolinone heterocyclic compounds. 4-(4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)phenyl)-1-thia-4-azaspiro[4.5]decan-3-one (5) was synthesized by facile and fast heterocyclization reaction, which further underwent condensation with 4-chlorobenzaldehyde to afford 2-(4-chlorobenzylidene)-4-(4-(6,7-dihydrothieno[3,2-c] pyridine-5(4H)-ylsulfonyl)phenyl)-1-thia-4-azaspiro[4.5]decan-3-one (6). Resultant compound was used as precursor for the preparation of some bioactive fused heterocyclic compounds (7–10). All the synthesized compounds were duly characterized by elemental analyses and various spectroscopic techniques. All the synthesized compounds were screened for their antimicrobial activity and it was observed that as the fusion of heterocyclic rings increases its shown higher antimicrobial activities.