Sun Hong-jie
2005
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Journal
Journal of Anhui University
Abstract
Trans-p-Pentylcyclohexylbenzylketone is an intermediate to synthesize ethane′s liquid crystal.Target molecule was prepared from trans-p-Pentylcyclohexanecarboxylic acid through acylchloridation、ammonolysis、dehydration and grignard reaction.Synthesis condition of grignard reaction was researched,and the optimum reaction conditions were as follows : with tetrahydrofuran and methylbenzene as reaction solvents,n(C_(6)H_(5)CH_(2)MgCl)∶n(C_(5)H_(11)C_(6)H_(10)CN)= 1∶1.5,and 10h treaction time,a total yield of 41.5% was achieved.The structure of the compound was characterized by IR,~(1)HNMR.