G. Caliendo, R. Carlo, R. Meli
1993
Citations
0
Influential Citations
31
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract A series of 1- and 2-[3-[4-( X )-1-piperazinyl]-propyl]benzotriazoles were prepared and evaluated for their trazodone-like pharmacological profile; as preliminary pharmacological screening, the compounds were tested for their antiserotonergic, antiadrenergic and antihistaminic in vitro activity as well as for their analgesic in vivo action. Structure-activity relationships showed that among the synthesized compounds, the analogues bearing on the 4-piperazine nitrogen either an unsubstituted phenyl ring or a 2- or 3-chloro phenyl moiety show a pharmacological profile similar to that of the antidepressant trazodone.