S. Xu, Qun Hao, Hongyan Li
Mar 16, 2017
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Influential Citations
8
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Journal
Organic Process Research & Development
Abstract
An improved process for the synthesis of antidiabetic drug trelagliptin succinate through unprotected (R)-3-aminopiperidine was described. The impurity profile with different conditions of the key substitution was illustrated, and then the best reaction condition was identified. The optimizations also included the bromination of 4-fluoro-2-methylbenzonitrile so that the process became efficient and concise.