I. Nizhenkovska, Kateryna V. Matskevych, O. Golovchenko
Oct 29, 2020
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Abstract
1,3-oxazole derivatives are known to exhibit a wide range of biological effects. They are a part of natural bioactive molecules and synthetic drugs (Harris et al., 2005; Niraimathi et al., 2011). 5amino-1,3-oxazoles are often regarded as masked peptides, so such substances are perspective pharmacophore groups for modification of the peptide chain. In addition, dehydroamino acids are of great interest among biochemists and pharmacologists. Therefore, the synthesis of novel compounds of peptide nature, which contain fragments of dehydroamino acids and 5-amino-1,3oxazole ring, is promising for further pharmacological studies as new bioregulators of various actions. Phosphorylated oxazole (POD) derivatives are one of the perspective groups of this type of compound with vasodilatation properties. Only sporadic studies of the vasoactive action of this group of compounds in vitro have been identified in the literature, which have not yet been investigated in vivo (Iakovenko et al., 2013). The above was the basis for pharmacological study of the antihypertensive action of these substances with the prospect of their recommendations for further study and use as medicines for the treatment of hypertension.