A. K. Agarwal
Apr 23, 2012
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Journal
The Pharma Research
Abstract
4- Fluoro phenacyl pyridinium bromide was prepared by the interaction of 4 – fluorophenacyl bromide and pyridine, in benzene under reflux temperature. The pyridinium salt on treatment with K2CO3 in aqueous solution, gave 4 – flurophenacylpyridinium ylide. The ylide, on reaction with substituted benzlideneacetophenones in presence of ammonium acetate in acetic acid or methanol, gave symmetrical pyridines having different substituents at 2, 4, 6 – positions. Similarly, when the ylide was coupled with substituted benzylidene – 4 – acetophenones, 2, 6 (4 – fluorophenyl) - 4 – substituted phenyl pyridine, symmetrical pyridines were formed in good yields. Synthesis of symmetrical pyridines having substituents, involving the condensation of 4-fluorobenzylidene pyridinium ylide with 4 – fluorobenzylidene – 4 – fluoroacetophenone in ammonium accetate. All the new pyridines were confirmed by NMR Specteral data.