S. Masi, S. Top, L. Boubekeur
May 1, 2004
Citations
1
Influential Citations
46
Citations
Journal
European Journal of Inorganic Chemistry
Abstract
The preparation of new tricarbonyl(cyclopentadienyl)rhenium and tricarbonyl(cyclopentadienyl)technetium derivatives is described. The approach used was applied to a cold target model, 17α-ethynylestradiol substituted at the 17α position by a ketotricarbonyl(cyclopentadienyl)rhenium group. The novel organometallic reaction applied here, when extended to potential radiopharmaceuticals, consists of a cyclopentadienyl-ligand transfer between ketoferrocenes and fac-[99mTc(H2O)3(CO)3]+ in a water/DMSO 1:1 mixture. This reaction lead to the synthesis of a new estradiol derivative, labeled with 99mTc. The synthesis of another product was performed by using [99TcCl3(CO)3]2− as the Tc precursor and its X-ray crystal structure was determined. In each case high yields were obtained. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)