M. E. Kodadi, M. Benamar, Bouabdallah Ibrahim
Aug 28, 2007
Citations
0
Influential Citations
22
Citations
Quality indicators
Journal
Natural Product Research
Abstract
Two new tripodal compounds—4-{bis[(3,5-dimethyl-1H-pyrazole-1-yl)methyl]amino}butane-1-ol (1); ethyl 1-[((2-hydroxyethyl){[3-(ethoxycarbonyl)-5-methyl-1H-pyrazole-1-yl]methyl} amino)methyl]-5-methyl-1H-pyrazole-3-carboxylate (2) were reported. The evaluation of the cytotoxic properties in vitro of these ligands, was examined on two tumor cell lines—P815 (mastocytome murine) and Hep (carcinoma of human larynx). The concentration required to induce 50% of lysis (IC50) was more pronounced against P815 cell line (IC50: 39.42 µg mL−1 for the compound 1 and 97.74 µg mL−1 for the compound 2) than the Hep cell line (IC50: 83.49 µg mL−1 for compound 1 and 185.30 µg mL−1 for compound 2). Statistical analysis shows that the compound 1 is two to three folds more cytotoxic than the compound 2 (p < 0.05). Interestingly, the cytotoxic activity depends strongly on both the substituents linked to the aminic nitrogen and pyrazolic rings.