Mu-Wang Chen, Zhishi Ye, Zhangpei Chen
Apr 15, 2015
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Organic chemistry frontiers
Abstract
An enantioselective iridium-catalyzed hydrogenation of trifluoromethyl substituted pyridinium hydrochlorides is described. Introduction of a trifluoromethyl group increases the reactivity due to the electron-withdrawing effect. Three stereogenic centers could be generated in one operation. This methodology provides a convenient route to chiral poly-substituted piperidines with up to 90% ee.