Rebecca J. Andrew, J. M. Mellor
Sep 8, 2000
Citations
0
Influential Citations
37
Citations
Journal
Tetrahedron
Abstract
Abstract Syntheses of intermediate 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones are described from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one and α-aminoacids. In subsequent cyclisations pyrroles and other bicyclic heteroaromatics having trifluoromethyl substitution are obtained either by simple dehydration or with concomitant decarboxylation.