Kazuki Kurahayashi, Kengo Hanaya, Shuhei Higashibayashi
Jun 4, 2018
Citations
0
Influential Citations
6
Citations
Journal
Bioscience, Biotechnology, and Biochemistry
Abstract
ABSTRACT Trilobatin [4ʹ-(β-D-glucopyranosyloxy)-2ʹ,4”,6ʹ-trihydroxydihydrochalcone] was synthesized from commercially available naringin in three steps with an overall yield of 30%. The key step was the acid-catalyzed site-selective hydrolysis of terminal α-rhamnopyranosidic linkage in neohesperidose involved in naringin under controlled conditions, by applying a high-pressure steam sterilizer. GRAPHICAL ABSTRACT