G. Ciszewska, Heidi Pfefferkorn, Y. S. Tang
Aug 1, 1997
Citations
0
Influential Citations
9
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
(S)-(-)-N-Ethyl-N-methyl-3-[1-(dimethylamino)ethyl]carbamic acid, phenyl-2-3H-ester, (L)-2,3-dihydroxybutanedioic acid salt was synthesized via directed ortho-metallation methodology. (S)-(-)-N-Ethyl-N-methyl-3-[1-(di-(2H3)-methylamino)ethyl]carbamic acid, phenyl ester, (L)-2,3-dihydroxybutanedioic acid salt was synthesized from 3-hydroxyacetophenone. The molecule was resolved by classical diastereomeric salt formation and fractional crystallization. The carbon-14 analog,(S)-(-)-N-Ethyl-N-methyl-3-[1-(dimethylamino)ethyl-1-(14C)]carbamic acid, phenyl ester, (L)-2,3-dihydroxybutanedioic acid salt was constructed starting from 3-iodoanisole and featured the enantioselective reduction of a methoxylamine intermediate. © John Wiley & Sons, Ltd.