S. Landvatter, D. W. Blackburn, A. J. Villani
Feb 1, 1987
Citations
0
Influential Citations
2
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
SKF 82526 (6-chloro-7,8-dihydroxy-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine) has been synthesized in both racemic mono and enantiomerically pure ditritiated form; SKF 38393 (7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) has also been labeled with tritium. In each case labeling was accomplished via tritiation of the appropriate ring halogenated precursor with tritium gas over Pd catalyst in triethylamine in DMF.