J. Hoeffler, C. Grosdemange-Billiard, M. Rohmer
Jun 19, 2000
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Free 2-C-methyl- d -erythritol is utilised for isoprenoid biosynthesis by Escherichia coli mutants lacking the two first enzymes of the methylerythritol phosphate pathway, the deoxyxylulose phosphate synthase and isomero-reductase. For feeding experiments, this tetrol was synthesised with an overall 43% yield from readily available 1,2-O-isopropylidene-α- d -xylofuranose, including the possibility of tritium labelling.