Chengjie Feng
2011
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Journal
Central South Pharmacy
Abstract
Objective To improve the synthesis of tropisetron hydrochlorride.Methods Tropisetron hydrochloride was synthesized from indol-3-carboxylic acid by chloride acetylation and condensed with tropic alcohol sodium,followed by salt formation with hydrochlororic acid.Results This synthetic process avoided using the inflammable and explosive n-butyllithium and therefore ensured security and cost reduction and improved yield.Conclusion The process without separating the intermediates is simple and suitable for industry production.