B. Li
2014
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Quality indicators
Journal
West China Journal of Pharmaceutical Sciences
Abstract
OBJECTIVE To synthesize a novel series of 3- amidebenzamide derivatives and to study their anti- tumor activity in vitro. METHODS The target compounds were synthesized from 5- amino- 2- methylbenzoic acid and 5- amino- 2- chlorobenzoic acid by protection of 5- amino using Boc,formation of amide,deprotection and acylation,etc. The anti- tumor activity in vitro of these compounds was studied by MTT assay on prostate carcinoma cells PC- 3,ovarian carcinoma cells SKOV- 3,human colorectal cancer cells HCT116,human hepatocellular carcinoma cells Hep- G2,malignant melanoma cells A375,human lung carcinoma cells A549 and human erythroleukemia cells K562. RESULTS and CONCLUSION Nine new compounds were prepared,and the chemical structures were confirmed by1HNMR and MS. Preliminary anti- tumor activity in vitro displays that compound Ⅳh and Ⅳi exhibited good activity against chronic myelogenous leukemia.