Jianhui Gu, Jie Zhang, Xuan Wang
May 3, 2018
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Influential Citations
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Journal
Synthetic Communications
Abstract
ABSTRACT Umeclidinium bromide, a drug used for chronic obstructive pulmonary disease, is synthesized through a new intermediate of phenyl(quinuclidin-4-yl)methanone. This novel method with simple operation flow and cheap reagents, makes it suitable for scale up. The overall four-step process provides umeclidinium bromide in 29% yield and the purity up to 99.83%. The X-ray crystal structure of the drug molecule was first reported. GRAPHICAL ABSTRACT