Haruki Inada, M. Shibuya, Yoshihiko Yamamoto
Aug 13, 2020
Citations
0
Influential Citations
4
Citations
Journal
The Journal of organic chemistry
Abstract
The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products 2-arylglycines transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available L-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.