J. Fehrentz, E. Bourdel, J. Califano
Mar 7, 1994
Citations
0
Influential Citations
28
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthesis of chiral N-protected tetramic acid derivatives which are important precursors of β-hydroxy γ-amino acid under mild conditions is described. Reaction of urethane-N-carboxyanhydrides (UNCAs) with Meldrum's acid in the presence of a tertiary amine, followed by subsequent cyclisation produced tetramic acid derivatives. This procedure is applicable to Boc-, Fmoc- and Z- N-carboxyanhydrides.