Ya Zhou, Aaron B. Beeler, Sanghyun Cho
Jun 3, 2008
Citations
1
Influential Citations
23
Citations
Journal
Journal of combinatorial chemistry
Abstract
The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.