T. Morozumi, H. Uetsuka, M. Komiyama
Dec 15, 1991
Citations
0
Influential Citations
13
Citations
Journal
Journal of Molecular Catalysis
Abstract
Abstract 4-(Hydroxymethyl)phenol is selectively synthesized from phenol and formaldehyde by use of β-cyclodextrins (β-CyDs) carrying quaternary ammonium, glucose and maltose residues as catalysts. The chemical modification of β-CyD largely promotes the catalytic activity, especially the rate-accelerating effect. Yield of the desired para-substituted product (16.8 mol%) for the β-CyD having the quaternary ammonium substituent (0.3 M) is 7.3 times as large as that (2.3 mol%) for unmodified β-CyD (the selectivities are 80 and 79%, respectively). Selective synthesis of 4-(hydroxyethyl)phenol from phenol and acetaldehyde is successfully achieved also by use of the β-CyD derivatives having sugar branches, which is in marked contrast with the marginal activity of unmodified β-CyD.